Acotiamide hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

阿考替胺盐酸盐是阿考替胺的盐酸盐形式，阿考替胺是一种具有胃肠道 (GI) 动力增强活性的促动力剂。

Acotiamide Hydrochloride is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms.(In Vivo):Acotiamide monohydrochloride trihydrate (0.3, 1, 3 mg/kg; i.v./3, 10, 30 mg/kg; p.o.) increases the postprandial gastric motility index in a dose-dependent manner.Acotiamide monohydrochloride trihydrate (0.83 mg/kg; i.v.; once) inhibits AChE in rat stomach with IC50 of 1.79 μM.

Acotiamide monohydrochloride trihydrate (10, 30, 100 μM; 1 hour) reduces expression levels of IκB-α phosphorylation in LPS- and MCP-1-stimulated macrophage cell lines. Cell Viability Assay Cell Line:NR8383, macrophage Concentration:10, 30, 100 μM Incubation Time:1 hour Result:Significantly reduced both TNF-α and IL-6 productions in LPS/MCP-1-stimulated NR8383 cells.

Acotiamide monohydrochloride trihydrate (0.3, 1, 3 mg/kg; i.v./3, 10, 30 mg/kg; p.o.) increases the postprandial gastric motility index in a dose-dependent manner.Acotiamide monohydrochloride trihydrate (0.83 mg/kg; i.v.; once) inhibits AChE in rat stomach with IC50 of 1.79 μM. Animal Model:Male mongrel dogs (9-11 kg), Male beagle dogs (9.6-12.9 kg)Dosage:0.3, 1, 3, 10, 30 mg/kg Administration:Intravenous injection; once.Result:Increased the postprandial gastric motility.Animal Model:Male Sprague-Dawley rats (aged 6-7 weeks)Dosage:0.83 mg/kg Administration:Intravenous injection; once.Result:Effectively improved functional dyspepsia by inhibiting AChE in rat stomach.

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GPCR/G Protein

Melatonin Receptor

AChE

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773092-05-0

541.06

C21H37ClN4O8S

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (231.03 mM)

s1c(nc(c1)C(=O)NCCN(C(C)C)C(C)C)NC(=O)c1c(cc(c(c1)OC)OC)O.O.Cl.O.O

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(-20℃)

With Ice Pack

≥ 2 years